Search results for acetylsalicylic acid at sigmaaldrich. Acetylsalicylic acid side effects, uses, dosage, overdose. Material safety data sheet acetylsalicylic acid product observe all federal, state, and local environmental regulations. If not breathing give artificial respiration consult a physician. Acetylsalicyclic acid definition of acetylsalicyclic acid. The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with. Acetylsalicylic acid is used for the treatment of fever as well as inflammation and pain caused by various conditions such as arthritis, menstrual pain, headache, migraines, muscle. Safety data sheet northwest missouri state university. Ac158180000, ac158180025, ac158185000, ac385760000 synonyms. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910. There is no warranty of accuracy or completeness of any information contained herein. Synthesis of oil of wintergreen pre lab discussion. Buy acetylsalicylic acid 75mg150mg tablets at our pharmacy. One reagent lane fair lawn, nj 07410 for information in north america, call.
Aspirinalso known as acetylsalicylic acid is sold over the counter and comes in many forms, from the familiar white tablets to chewing gum and rectal suppositories. O acetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. Acetylsalicylic acid definition of acetylsalicylic acid by. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. Development of a new analytical method for determination of. This material is considered hazardous by the osha hazard.
Coated, chewable, buffered, and extended release forms are available. Sixty patients with 143 distal anastomoses of bypasses were randomized, 46 underwent repeat angiography after 4 months. Chapter 7 safe chemical use cornell ehs cornell university. Acetylsalicylic acid is a white crystal or powder that is essentially odorless and has a slightly bitter taste. Acetylsalicylic acid aspirin, a prodrug to salicylic acid, is made by an entirely different process. How many 80mg aspirin tablets would a 160 pound person have to consume to ingest the estimated ld50 for acetylsalicylic acid. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. Salicigen, an extract of willow and poplar bark, has been used as a pain reliever. Sigmaaldrich offers a number of acetylsalicylic acid products. Jul 27, 2017 acetylsalicylic acid get uptodate information on acetylsalicylic acid side effects, uses, dosage, overdose, pregnancy, alcohol and more. Excerpt from erg guide 154 substances toxic andor corrosive noncombustible.
O acetylsalicylic acid 2acetoxybenzoic acid aspirin formula. Basically i think that acetylsalicylic acid isnt very soluble in water because of its polarity. Aspirin material safety data sheet cas no 50782 sdsmsds. Will likely be mobile in the environment due to its water solubility.
Acetylsalicylic acid not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. The average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid combined with an inert binding material such as starch. Acetylsalicylic acid is a white crystal or powder that is. First aid measures always seek professional medical attention after first aid measures are provided.
So aso in the raman shft 550 cm1, there is a shift and this is a ccl bond, which indicates a different composition of the acetylsalicylic acid. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Synthesis of acetylsalicylic acid dan jones, josh schmidt abstract acetylsalicylic acid, commonly known as aspirin, is considered to be the most successful pharmaceutical product in the world. If you forget a dose, take it as soon as you remember. Other references state that a 10 g dose 143 mgkg may be fatal in humans. Precautionary statements p261 avoid breathing dust. E29 preparation of aspirin acetylsalicylic acid and thinlayer chromatography of analgesic drugs the task to prepare a pharmaceutical compound and test its purity. Acetylsalicylic acid aspirin is a nonsteroidal antiinflammatory drug nsaid with properties that inhibit the proinflammatory status of the brain. Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Aspirinalso known as acetylsalicylic acidis sold over the counter and comes in many forms, from the familiar white tablets to chewing gum and rectal suppositories. The expected concentrations in the samples were chosen in a way to be close to middle range. Aspirin is the most widely used overthecounter drug in the world.
Acetylsalicylic acid solubilty organic chemistry science. See actual entry in rtecs for complete information. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Effect of aspirin on disabilityfree survival in the healthy elderly pdf. Bioaccumulation accumulationno information available. In folk medicine, willow bark teas were used as headache remedies and other tonics. Oacetylsalicylic acid 2acetoxybenzoic acid aspirin formula. Immediately flush eyes with excess water for 15 minutes, lifting lower and upper eyelids occasionally. Organic chemistry ii january 30, 20 synthesis of aspirin acetylsalicylic acid using acid and base catalysis. If inhaled if breathed in, move person into fresh air.
Safety data sheet chandlergilbert community college. Oacetylsalicylic acid is the prototypical analgesic used in the treatment of mild to moderate pain. The skills by the end of the experiment you should be able to. In this lab, students will analyze aspirin acetylsalicylic acid tablets for the acetylsalicylic acid content, using a volumetric analysis technique called titration. I know that acetylsalicylic acid isnt very soluble in water. Please note that some chemicals, such as hydrofluoric acid, require use of a special antidote such as calcium gluconate gel and. Also,one mol of oh reacts with one mole of acetylsalicylic acid. Aspirin or acetylsalicylic acid acetosal is a drug in the family of salicylates, often used as an analgesic against minor pains and aches, antipyretic against fever, and antiinflammatory. Ive tried researching on the net and so far i havent really got it, but i think im onto something. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters 150 feet for liquids and at least 25 meters 75 feet for solids. For this reason, it is industrially synthesized on a massive scale, producing up. Safety data sheet according to 29cfr19101200 and ghs rev. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever.
In this lab, we synthesized aspirin using both acid catalysis and base catalysis. The only other information i know,is that the acetylsalicylic acid reacts with hydroxide ion,from a standardized sodium hydroxide solution. The msds sheet for acetylsalicylic acid estimates its oral, single dose ld50 as 357 mg per kg in humans. Fisher scientific one reagent lane fair lawn, nj 07410. Pdf multiple targets of salicylic acid and its derivatives in plants. Salicylic acid and its esters are used as food preservatives, in skincare products and other cosmetics, and in topical medicines. Development of a new analytical method for determination of acetylsalicylic and salicylic acids 725 following experimental outline. Pharmacokinetics and pharmacodynamics of acetylsalicylic acid. Not all of the mass of an aspirin tablet is acetylsalicylic acid, as there are starch binders added to hold the tablet together.
Methyl salicylate may be used by plants as a pheromone to warn other plants of pathogens such as tobacco mosaic virus. Ac158180000, ac158180500, ac158185000, ac385760000 synonyms. Material safety data sheets the syracuse city school district. Curiously, salicylic acid is also a metabolite of aspirin.
Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention. Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a pain killer. Msds contains all of the information required by those regulations. Methyl salicylate c6h4 ho cooch3, also known as salicylic acid methyl ester, oil of wintergreen, is a natural product of many species of plants. Synthesis of aspirin acetylsalicylic acid using acid and base catalysis chm 2211c. Abstract a new sensitive colorimetric method for determination of aspirin tablet in aqueous solution. How many moles of acetylsalicylic acid molarmass 180. Acetylsalicylic acid aspirin not listed not listed ec50 360 mgl 1 h ec50 900 mgl 1 h ec50. Acetylsalicylic acid asa makes the platelets in your blood less sticky. Synthesis of acetylsalicylic acid aspirin using acid. Acetylsalicylic acid an overview sciencedirect topics. Sds of acetylsalicylic acid, safety data sheets, cas 50782.
Dec 12, 2005 i know that acetylsalicylic acid isnt very soluble in water. Material safety data sheet acetylsalicylic acid if inhaled if breathed in, move person into fresh air. E29 preparation of aspirin acetylsalicylic acid and thin. Applications tn1071 page 3 of 8 experimental acetylsalicylic acid and related substances. Aspirin given shortly after a heart attack decreases the risk of death. Transfer of large quantities of flammables, acids, bases, or other hazardous materials. The first known use of an aspirinlike preparation can be traced to ancient greece and rome. Substitute less hazardous chemicals in your experiments whenever possible. Product and company identification acetylsalicylic acid. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. Specifies the medication aspirin acetylsalicylic acid, aspirin, arthritis foundation safety coated aspirin, bayer aspirin, bayer childrens aspirin, ecotrin, and many others, a drug used for the treatment of arthritis, pain, inflammation, and fever. Show this safety data sheet to the doctor in attendance. Section 1 chemical product and company identification.
The effect of lowdose acetylsalicylic acid 100 mgday upon bypass patencyrate and clinical course after aortocoronary bypass surgery was investigated in a randomized, placebocontrolled clinical trial. Material safety data sheet page 1 of 2 acetylsalicylic acid. Contact a licensed professional waste disposal service to dispose of this material. Pdf salicylic acid sa is a critical plant hormone that is involved in many. Salicylic acid, whose name comes from salix, the willow family of plants, was derived from willow bark extracts. Pharmacokinetics and pharmacodynamics of acetylsalicylic acid after intravenous and oral administration to healthy volunteers j nagelschmitz,1 m blunck,1 j kraetzschmar,1 m ludwig,1 g wensing,1 t hohlfeld2 1bayer healthcare ag, clinical pharmacology, wuppertal, germany. In a business making drugs based on, for example, acetylsalicylic acid, a product that has been on the market for well over 100 years, the chances are there is often no new knowledge to be gained from psurs periodic safety update reports and single case handling, yet the dogged reporting and analysis still has to take place in order to. Water is a polar molecule, and i think acetylsalicylic acid isnt. In case of skin contact wash off with soap and plenty of water. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
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